Violation of the hormonal balance in the male body, in particular – increasing the level of the hormone dihydrotestosetron, leads to the development of prostatic hyperplasia, a concomitant manifestation of which is the difficulty of outflow of urine in acute or latent form. To inhibit (prevent the production of) dihydrotestosterone synthetic substance of selective action is used Dutasteride, which is part of preparations with various trade names.
Dutasteride was developed and patented for the first time in the United States of America; it was produced in mass production in 2001 as part of a drug under the trade name Avodart, which is still used today. In 2015, the term of the patent for the substance ended and it began to be used in the production of generic drugs.
The increase in the level of the hormone dihydrotestosterone in men leads to an uncontrolled proliferation of the prostate gland with the subsequent possible degeneration into a malignant form.
In addition, the elevated background of dihydrotestosterone in men is the cause of alopecia (hair loss on the head) and hirsorutism (body hair in women).
Hyperplasia of the prostate gland is considered as a precancerous state of the body, requires special attention and corrective therapeutic and sometimes surgical interventions. One of the substances that selectively reduced the level of dihydrotestosterone was Dutasteride.
The substance inhibits the activity of 5-alpha-reductase enzymes of the 1 st and 2 nd types, acting on the hormone testosterone, preventing it from turning into an excess amount of dihydrotestosterone.
The prostate gland, not getting supernormal hormone dihydrotestosterone, stops uncontrolled proliferation of its tissues and the process of hyperplasia stops. As a result of a decrease in the volume of the gland, the compression of the urinary tract ceases and urine output is facilitated, and, consequently, inflammatory stagnant phenomena also disappear.
Thanks to the action of this medication, many patients managed to avoid surgical intervention and monitor the condition of the gland, restraining the progression of its growth.
Capsules are taken orally, one per day, with water. The capsule itself can not be chewed or poured into the oral cavity, since the active substance is capable of damaging the mucous membrane of the oral cavity and pharynx.
According to the instructions for use, the drug is recommended to be taken regardless of food intake, but there is evidence that a one-time intake with food reduces the absorption and concentration level of the active ingredient in the body.
The maximum concentration of the substance in the blood plasma is fixed after 3 hours from the moment of use. Given the daily intake of 0.5 mg dutasteride in the body after a month of its intake, its serum concentration is 65 percent, and after 3 months it reaches 90 percent.
Improvement in the dynamics of the urological orientation is evident already in the first month of treatment. Take Avodart should be a course of 3 to 6 months in a mono-or combination therapy. Patients with hyperplasia of the gland clinically demonstrated a decrease in the levels of the prostatic specific antigen level, in comparison with the initial one, by 50% after two weeks from the beginning of the drug application.
Scientifically substantiated and confirmed data have been obtained that the Avodart containing dutasteride causes anomalies of the genital organs in boys, during the intrauterine development phase.
The frequency of manifestations of side effects is directly related to the individual characteristics of each individual organism and the duration of the course of administration the longer the time of application, the more likely the risk of undesirable effects.
Sally, 29 years old
“Although Dutasteride is not allowed in America, it is actively promoted through the Internet as a remedy against baldness. And of course, online stores (pharmacies) are selling. ”
Racho, 32 years old
“It is simply allowed for the treatment of prostate cancer, as the effectiveness of the use for these purposes is confirmed by clinical studies.”
Jessie, 31 years old
“It is one of the most authoritative experts in the world on the problem of drug treatment of alopecia.”